Dual action calcium-sensing receptor modulator unmasks novel mode-switching mechanism
… NPS2143 weakly inhibited Ca 2+ o potency (2-fold) (Figure 3d … of the ligand core dictates
PAM versus NAM activity. For … poses due to its flexible trans-1,2-disubstituted cyclohexane ring…
PAM versus NAM activity. For … poses due to its flexible trans-1,2-disubstituted cyclohexane ring…
[HTML][HTML] Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells
R Pais, FM Gribble, F Reimann - Peptides, 2016 - Elsevier
… the calcium sensing receptor CaSR in peptone sensing in … In the presence of Calhex 231
hydrochloride (10 μM) which … In this study, we observed a strong inhibition of the peptone-…
hydrochloride (10 μM) which … In this study, we observed a strong inhibition of the peptone-…
Targeting human astrocytes' calcium-sensing receptors for treatment of Alzheimer's disease
A Chiarini, U Armato, JF Whitfield… - Current Pharmaceutical …, 2017 - ingentaconnect.com
… N1-Benzoyl-N2-[1-(1naphthyl)ethyl]-trans-1, 2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide
(Calhex 231) as a new calcium…
(Calhex 231) as a new calcium…
Fluorescent sensors for imaging of interstitial calcium
AA Valiente-Gabioud… - Nature …, 2023 - nature.com
… Calcium Sensing Receptor (CaSR), a G-protein coupled receptor that, among other ligands,
… The crystals were cryoprotected with addition of 30% of ethylene glycol and flash-frozen in …
… The crystals were cryoprotected with addition of 30% of ethylene glycol and flash-frozen in …
[HTML][HTML] Family C G-protein-coupled receptors in Alzheimer's disease and therapeutic implications
I Dal Prà, U Armato, A Chiarini - Frontiers in pharmacology, 2019 - frontiersin.org
… Finally, neutral allosteric ligands (NALs) bind their sequence on a receptor but do not …
selective calcium-sensing receptor (CaSR) negative allosteric modulators (NAMs) (or calcilytics). …
selective calcium-sensing receptor (CaSR) negative allosteric modulators (NAMs) (or calcilytics). …